Abstract
Summary
A study has been made of the effect of 7 dyes of the phenazine, oxazine and thiazine series on the in vitro coagulation times of normal and heparinized rabbit plasma. Toluidine Blue, Azure A, Neutral Violet and Neutral Red effectively counteract the anticoagulant action of heparin but the amount of each dye required for this antiheparin effect is critical. At concentrations below the critical level the dyes had little or no effect upon the coagulation system studied. At concentrations above the critical level all the dyes produced a progressively increased incoagulability of the system. This anticoagulant effect of the dyes is related to concentration and the action is on some substance other than heparin.
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