Disappearance of Hyaluronidase from the Blood of Albino Rats

Abstract

Summary

Following the intravenous administration of testicular hyaluronidase to albino rats, the following changes were noted:

1. The maximum concentration of the enzyme was attained within 5 minutes and diminished rapidly, so that at one hour it was no longer detected by turbidimetric methods.

2. Approximately 2% of the hyaluronidase appeared in the urine in an active form.

3. The plasma hyaluronidase inhibitor level was depressed for 8 hours and returned to normal withini 24-72 hours.

4. No significant proteinuria resulted.