The Development of Hypertension and Nephritis in Normal and Adrenalectomized Rats Treated With Cortisone. ∗

Abstract

Summary

1. The administration of cortisone did not prevent the development of experimental cytotoxic serum nephritis in the rat.

2. Moderate hypertension developed in nephritic rats with intact adrenal glands when injected with cortisone, whereas striking hypertension appeared in adrenalectomized nephritic rats similarly treated.

3. The nephritic rats rendered hypertensive by the administration of cortisone presented no greater histological evidence of renal damage than did normotensive control nephritic animals.