Abstract
Summary
Further studies on the effect of different quinone derivatives with varying degrees of acid-formation inhibiting power, as determined in vitro, and with or without vitamin K activity, on dental caries activity were carried out in hamsters. In these studies the following quinone derivatives were tested: Dicalcium salt of methylnaphthohydroquinone diphosphate, methylnaphthohydroquinone disuccinate, anthraquinone sulphonic acid, and dichloronaphthoquinone. The compounds were used in higher amounts than those used in the previous experiment.
The results showed that none of the quinone derivatives tested exerted beneficial effect against dental caries activity, as compared with the control group. Thus the present experiment confirms the negative findings of previous studies, clinical as well as experimental, on this subject, and indicates that the use of vitamin K active compounds or other quinone derivatives as a control measure against human dental caries should be discouraged. Furthermore, some other implications of these studies have been discussed.
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