Effect of Pilocarpine on Epinephrine Reversal Produced by 2-(N-p'toly-N-(m'-hydroxyphenyl)-aminomethyl)-Imidazoline. HCl (C-7337) ∗

Abstract

Conclusion

1) Epinephrine reversal produced by 2-(N-p'tolyl-N-(m'-hydroxy-phenyl)-aminoethyl)-Imidazoline HCl (C7337) may be abolished lby the injection of pilocarpine and other parasympathomimetic agents.

2) The reversing action of such an adrenolptic agent may be reinstated by injection of atropine.

3) Pilocarpine is dm effective in decreasing the depressor action of isopropyl norepinephrine and of acetylcholine.