Abstract
Summary and Conclusions
1. The apparent volume distribution of PXH is 35.9 (S.D. ± 7.3) % of body weight.
2. If the priming dose is omitted and the plasma level allowed to rise slowly during an intravenous infusion of PAH, the plasma concentration appears to reach about 90% of its eventual level in 75 minutes, 95% in 100 minutes, and 99% in 150 minutes in the average patient, so long as the plasma concentration remains below that of beginning saturation of thfe tubular excretory mechanlism.
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