Abstract
Summary
Epinephrine protects adrenal insufficient rats from the edema and mortality caused by the intraperitoneal administration of egg white. Mortality is prevented by doses (0.04 mg/kg) which are not able to prevent edema in rats with intact adrenals.
The antihistaminic Phenergan, N-dimethyl-amino-2-propyl-l-thiodiphenylamine (“3277 RP”), in doses as low as 5 mg/kg prevent death from egg white edema in adrenalectomized rats.
“SY-28”, N-(2-bromoethyl)-1-naphthalene-methylamine hydrobromide, a Dibenamine congener possessing both antihistaminic and adrenergic blocking activity, also prevents the edema and death, but is in itself toxic to adrenalectomized rats.
“SKF-501”, N-(9-fluorenyl)-N-ethyl-β-chloroethylamine, a Dibenamine cogener with potent adrenergic blocking powers but with a low toxicity and without antihistamine action, also inhibits the edema and decreases the mortality.
The possible modes of action are discussed.
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