Abstract
Summary
Acute toxicity studies were made on 3 different samples of cottonseed pigment glands administered orally to 228 rats in the form of slurries made with either distilled water or 2% ferrous sulfate solution. The LD50 values for the samples when administered in water were, respectively, 1140, 1490 and 2290 mg/kg. When given in 2% ferrous sulfate solution the samples were detoxified so that even such high doses as 7000 mg/kg for each were no longer toxic. There was little effect on the body weight of all 99 rats which survived doses of ferrous sulfate-treated cottonseed pigment glands 3 to 6 times the LD50 value for water-suspended glands. Administration of pigment glands in 0.5% FeSO4 did not detoxify them, and led to the death of all 24 rats given this preparation.
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