Abstract
Summary and Conclusions
A choleretic response to cinchophen was observed in guinea pigs.
The chinchophen output in the bile was found to be greatest in guinea pigs and to decrease in the following order: rats, cats and rabbits.
The following is the order found for susceptibility to cinchophen ulceration: cat, dog, guinea pig and rat. Rabbits were fund completely resistant.
There appears to be no abvious relationship between the species susceptibility to cinchophen ulceration and the choleretic response of that species to cinchophen or to the concentration of cinchophen in the bile after intravenous administration.
It would appear that the ulcer susceptible animals investigated have a low basal bile flow whilst the unsusceptible have a high flow.
Get full access to this article
View all access options for this article.