Abstract
Summary
The administration of large doses of 2,6-diaminopurine in mice and rats can result in death within a few hours. In dogs, large doses caused protracted vomiting, hemorrhagic diarrhea, dehydration and death within 48 hours. Doses permitting survival of rats and dogs for 24 hours or longer produced depletion of bone marrow and damage to epithelium of colon and ileum. The course of intoxication and changes in bone marrow permit a differentiation between the actions of 2,6-diammopurine and a folic acid-antagonist like 4-aminopteroylglutamic acid.
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