Abstract
Summary
Eleven steroid compounds have been studied as to their influence on sodium excretion in adrenalectomized rats. Desoxycorticosterone caused significant retention at one microgram, and the acetate was effective at 25 micrograms, the lowest concentration studied. Δ4-pregnenol-21-trione-3,12,20-21-acetate gave a significant retention at 1340 micrograms. 17-Hydroxycorticosterone caused a significant excretion of sodium.
The following steroids were found to be negative: 11-dehydrocorticosterone acetate (100 μg), pregnanetrione-3,11,20 (200 μg), corticosterone (400 μg), allopregnanepentol-3 (β), 11(β), 17(α), 20, 21-3(β), 20, 21-tri-acetate (800 μg), allopregiianetriol-3(β), 17 (α), 21-one-20 (800 μg), testosterone (2000 μg), estradiol (2000 μg), and pregnanetrione-3,12,20 (2000 μg).
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