Abstract
Summary
The absorption, excretion, and tissue-distribution of 4 compounds of the 9-aminoacridine series have been studied in rats at oral dose levels ranging from 50 to 500 mg/kg. At any dose level Acranil concentrates in the tissues to the greatest extent, while the other compounds follow in this order: Win 2390, 2389, 2333. For any single compound, the tissue concentrations ordinarily increase with the dose, the largest amount being found in the liver. In order of increasing rate of absorption the compounds are Win 2390, Win 2389, Acranil, Win 2333 but none of these is as completely absorbed: within 24 hours as has previously been reported for Atabrine.
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