Abstract
Summary and Conclusions
The administration of Rose Bengal and ultraviolet irradiation in rabbits results in rapid and marked increase in the excretion of urinary coproporphyrin Type III to values 17 to 40 times those in the controls, returning to normal by the 5th day. Neither the dye alone nor the irradiation alone had any effect.
Simple hemolysis by distilled water had no effect upon the urinary coproporphyrin excretion. Phenylhydrazine produced a slight delayed increase of coproporphyrin excretion believed to be due largely to an increase of coproporphyrin Type I, as a result of increased erythropoiesis.
Additional studies are being undertaken in an attempt to discover the origin of the coproporphyrin excreted and the effects of other photodynamic compounds.
These results constitute the first demonstration that photodynamic activity causes a marked increase in the excretion of coproporphyrin III.
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