Abstract
Conclusions
In rabbits, doses of acetylcholine which do not provoke convulsions induce hyperglycemia.
This increase in blood sugar is prevented by the synaptic blocking agent tetraethylammonium, by nembutal and by removal of both adrenal glands.
The acetylcholine-hyperglycemia thus is induced by adrenal synaptic stimulation, which increases epinephrine output.
The acetycholine and epinephrine hyperglycemia are not abolished by an adrenolytic agent (SY 28). The hyperglycemia induced by high doses of an anticholinesterase drug (Nu-683) is also prevented by tetraethylammonium.
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