Abstract
Comment and Conclusions
From these experiments it would seem that saponin has no effect on the receptors responsible for the agglutination of chicken erythrocytes by influenza virus. Internal receptors, if such exist, are not exposed during the lytic process. The agglutinability of saponin-lysed cells by the virus is, in all probability, due to unaltered surface receptors and not to any substance associated with the nucleus. This interpretation is valid, however, only if it can be assumed that virus particles do not penetrate to the interior of the erythrocytes during treatment with the virus. That such a process could occur seems unlikely in view of present knowledge concerning the interaction between red cell and virus.
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