Influence of Cells and Plasma on In vitro Survival of Malaria Sporozoites. ∗

Abstract

Summary

In a study of the role of cells and plasma in retention of infectivity of sporozoites of P. cathemerium 3H2 in canary blood and the failure of such retention in hen blood, it was found that (a) survival occurs in hen whole blood provided a small amount of canary whole blood is present; (b) it does not occur in either canary or hen plasma alone; (c) it occurs in either canary or hen plasma if canary cells are present whether or not hen cells are simultaneously present but does not occur in either plasma if only hen cells are present; (d) it occurs in canary plasma to a greater extent if canary white cells (somewhat contaminated with canary red cells) are present than if canary red cells (somewhat contaminated with white cells) are present. The possible significance of the findings is discussed.