Abstract
Summary
1. Purified testicular hyaluronidase had no effect on the normal or altered permeability of skeletal muscle, cardiac muscle, or of isolated frog skin.
2. Hyaluronidase strikingly increased the permeability of the lens capsule and urinary bladder membranes, and abolished their semipermeable character.
3. The enhancing effect of hyaluronidase on osmosis through the bladder membrane was increased by desoxycorticosterone acetate.
4. Adrenal cortical extract, testosterone, and cholesterol abolished the enhancing effect of hyaluronidase. Estrone, Equilin, and Equilenin reversed the direction of flow through hyaluronidase treated membranes.
5. Hyaluronidase did not alter the complete inhibition of osmosis through the bladder membrane of rabbits which had been exposed to an alarming stimulus.
6. The products released in vivo during the alarm reaction rendered bladder membranes impermeable even in the presence of hyaluronidase.
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