Abstract
Summary and Conclusions
1. Of 78 animals with severe experimental frostbite 30 cases of infection with Pseudomonas aeruginosa (B. pyocyaneus) occurred, although the frozen area was treated locally with penicillin ointment.
2. Of 212 animals with the same degree of cold injury and treated with 3% sulfamylon ointment, only 4 animals developed local infection with Pseudomonas aeruginosa. In 180 of these animals the dressings were changed daily and none became infected. The dressings of 32 animals were changed every 2 to 4 days; in this group 4 infections occurred.
3. Sulfamylon is superior to penicillin in its effect on Pseudomonas aeruginosa infections.
4. It is possible to control the infection due to Pseudomonas aeruginosa in experimental frostbite by daily local application of sulfamylon.
We wish to give credit to Mr. Allyn Kimball of the Department of Biometrics, School of Aviation Medicine, Randolph Field, Texas, for making the statistical analyses of the experimental data.
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