Effect of Adrenergic Blocking Agents on the Cutaneous Action of Epinephrine

Abstract

Summary

1) Both Dibenamine and SY-28 were absorbed by the intact rabbit skin and were capable of blockmg the vasoconstriction produced by intracutaneously administered epinephrine. By this route SY-28 was approximately 5 times as potent as Dibenamine.

2) When administered by ion transfer, the penetration of both drugs into the skin was significantly facilitated.

3) Both blocking compounds were fixed locally in the skin. Contiguous untreated areas were still capable of responding to epinephrine.

4) By the intravenous route, SY-28 was approximately 8 times as potent as Dibenamine.

5) The “epinephrine reversal” phenomenon has been noted for the first time in the skin of the rabbit and suggests the presence of vasodilator fibers.