Abstract
Summary
The effect of several dihydrogenated derivatives of ergot were studied on rate of growth, production of gangrene and survival, as compared with ergotamine tartrate. None of these materials inhibited growth consistently; none inhibited growth as much as ergotamine tartrate. None of the dihydrogenated derivaties caused gangrene; in contrast, ergotamine produced gangrene in 80% of the rats. The survival of rats receiving ergot alkaloids or dihydrogenated ergot derivatives was equal to or better than that of the controls.
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