Abstract
Summary
1. The excretion of subcutaneously administered radiocalcium has been studied in normal rats.
2. The amount of labeled calcium injected appeared to be an important factor in determining the relative amounts of radiocalcium excreted in the urine and feces. When the quantity of labeled calcium injected was increased from 0.07 mg to 14 mg the fraction of the excreted radiocalcium which appeared in the urine in the first 24 hours increased from a relatively small value to a value approaching or slightly exceeding the amount of radiocalcium escreted in the feces. During a 9-day esperimental period the amount of radiocalcium escreted in the feces, when either 0.07 or 0.14 mg of labeled calcium was administered, greatly exceeded the amount excreted in the urine.
3. The distribution of radiocalcium in the tissues and contents of the stomach, small intestine, cecum, and colon was determined at 1, 3, and 6-hour intervals after the administration of a dose of labeled calcium. The results of these experiments indicate that there is little or no active excretion of calcium through the wall of the large intestine.
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