Abstract
Summary
Administration of 15 /xg per 100 g body weight of vitamin B12 to rats preceding acute C:C14 intoxication inhibits the development of histologic changes, especially fatty metamorphosis and depletion of ribonucleic acid. In addition, there is less deposition of lipids determined biocheamically and less BSP retention than in the intoxicated controls. These results are tentatively related to an effect of vitamin B12 on cytoplasmatic ribonucleic acid, which has been shown to disappear early in hepatic, injury.
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