Abstract
Summary
Incubation of normal human serum and that of patients with disease not involving the liver results in a drop in free cholesterol of more than 30% without change in the total cholesterol. The reaction is probably due to an enzyme, as the decrease does not occur when the serum is heated to 56° before incubation.
In this small series, the decrease in free cholesterol with incubation was usually less than normal with disease of the liver parenchyma and occasionally with extra-hepatic obstructive jaundice. The decrease in free cholesterol apparently did not parallel changes in serumj billirubin, alkaline phosphatase, serum albumin, or the cephalin flocculation test. There appeared to be some correlation with the percentage of cholesterolesters in the control serum.
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