Abstract
Summary
Diabetes was prevented in 9 of 10 rabbits given alloxan by temporary occlusion of the celiac and superior mesenteric arteries. The remaining animal developed moderate, delayed diabetes with mild histological changes in the islets of Langerhans.
Severe hypoglycemia was observed in several of the rabbits which failed to develop diabetes and which failed to show any histological change in the islets of Langerhans or the liver when examined at 2 to IS days.
These experiments indicate that alloxan diabetes is pancreatic in origin but suggest that the hypoglycemic phase is either extrapancreatic in origin or may be produced by the action of very small quantities of alloxan insufficient to produce detectable changes in the islets of Langerhans.
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