Abstract
Summary
Maeroscopically and microscopically, oviducts of frogs receiving aminopterin (4-amino pteroylglutamic acid) failed to respond to the growth stimulating action of estradiol. However, a significantly greater number of mitotic figures were visible in these oviducts, Evidence is presented to suggest that the folic acid antagonists may exert their growth inhibitory action by interfering with folic acid utilization in the organism, with a consequent reduction in nucleic acid synthesis, and a retardation of the rate of cell division.
Get full access to this article
View all access options for this article.