Lack of Identity of Hyaluronidase Inhibitor and Certain Mucoproteins in Blood Serum. ∗

Abstract

Summary and Conclusions

1. Electrophoretically and chemically separated fractions of human serum containing high concentrations of mucoproteins showed no increase in non-specific hyaluronidase inhibitor when compared to native serum or other mucoprotein-poor fractions of serum.

2. In children suffering from “lipoid nephrosis” the hyaluronidase inhibitor levels of the serum were higher while the muco-protein levels were significantly lower than normal.

3. In spite of the striking statistical correlation existing between the serum levels of mucoprotein and non-specific hyaluronidase inhibitor in a wide variety of human diseases, marked disparity in the serum levels of these substances occasionally occurs.

4. On the basis of these findings the lack of identity of the non-specific hyaluronidase inhibitor and these serum mucoproteins is pointed out.