Urinary Excretion of Amino-acids During Alloxan-induced Diabetes in Rats. ∗

Abstract

Summary

Nitrogen balance studies on 3 male rats during periods of normal control, of alloxan-induced diabetes with insulin therapy, and of fatal acidosis after withholding insulin, are reported.

The pattern of excretion of urinary amino-acids, and the ratio of total amino-acid nitrogen to total urinary nitrogen remained essentially unchanged throughout the 3 periods, including the terminal stage with greatly increased losses of total nitrogen.