Abstract
Summary
Approximately 60% of the succinoxidase activity of rat pituitary glands were found to be associated with the large granule fraction, and more than 50% of the gonadotrophin of these glands was associated with two granule fractions isolated from sucrose homogenates by differential centrifu-gation. The supernatant fraction from which the granules were removed contained the remaining gonadotrophic activity. The gonadotrophin can be extracted from the isolated granules with isotonic sodium chloride solution.
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