Abstract
Summary
1. Ninety compounds related to pteroylglutamic acid have been tested for chemo therapeutic effect against transmitted leukemia Ak 4 in mice.
2. Eighty-two of these compounds showed no chemo therapeutic effect by this particular technic.
3. Four showed slight to moderate effect.
4. Four compounds, 4-amino-N10-methyl-pteroylglutamic acid, 4-amino-9-methyl-pte-roylglutamic acid, 4-amino-9710-dimethyl-pteroylglutamic acid, and 2,6-diaminopurine have definite chemotherapeutic activity as demonstrated by approximately doubling the average survival time of the mice treated with these compounds.
5. The occurrence of an amino substitution in the second and fourth positions of the pyrimidine ring in all these active compounds has been noted.
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