Abstract
Summary
In vivo and in vitro experiments indicated that the inhibition of pyruvate oxidation occurred in animals injected with bacterial endotoxins. The inhibitory factor was probably identical with the toxic “antigéne complet” of Boivin and Mesrobeanu. It is suggested that the inhibition of pyruvate oxidation plays an important role in the toxic effect of endotoxins. The exact mechanism of the inhibition of pyruvate oxidation and the identification of the inhibitor as well as the biochemical nature of other components of the endotoxins remains to be further investigated.
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