Abstract
Summary
Eighteen extensively depancreatized male rats and 20 normal rats were force-fed a medium carbohydrate diet. Following periods of adaptation and control, all of the animals were tested for their resistance to twice daily injections of regular insulin. The initial dose was 5 units and was increased in increments of 5 units per dose every second day until the animal died. The average lethal dose for the depancreatized rats was 50.5 units per 24 hours as compared to an average of 68.5 units for the normal animals. This difference in averages was calculated to be statistically significant.
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