Abstract
Summary
WIN 1539, a new potent synthetic analgesic related chemically to Demerol, was found to have a stronger spasmolytic action than Demerol on the stimulated isolated intestinal strip. A decrease in tone of the intact small intestine of the dog was observed, WIN 1539 caused a greater delay than Demerol in the emptying time of the rat's stomach but morphine retarded emptying more than either of these drugs. Demerol caused a stimulation of the intact rat's stomach whereas WIN 1539 and morphine decreased the motility of this organ.
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