Abstract
Summary
Conditions have been established for the production of gastric lesions in guinea pigs by injection of aqueous histamine without considerable loss of animals due to fatal bronchial spasm.
Tagathen causes a very pronounced reduction in the incidence of gastric lesions produced by this method.
In view of the favorable results obtained, it would seem that a study of the mechanism involved in the anti-ulcer effect produced by antihistaminic compounds of this type, should be made.
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