Abstract
Summary
The adrenal cholesterol and ascorbic acid levels were studied in relation to the stainable lipids of the gland in rats treated with a lyophilized anterior pituitary preparation (LAP), given alone or in conjunction with a synthetic folliculoid (stilbestrol):
1. In stilbestrol treated rats, an almost total depletion of stainable lipids was observed in conjunction with low cholesterol and ascorbic acid values.
2. LAP caused accumulation of sudanophilic lipids in the adrenal cortex but significantly lowered the cholesterol and ascorbic acid levels.
3. A similar dissociation of sudanophilic material from cholesterol and ascorbic acid, was even more evident when LAP was administered concurrently with stilbestrol. The effect of stilbestrol on sudanophilia was counteracted by LAP.
4. These observations show that the corticotrophic effect of folliculoids cannot be solely ascribed to the liberation of anterior pituitary corticotropin such as is present in LAP.
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