Abstract
Summary
A method is described for the isolation and identification of 4,4′-diamino-diphenylsulfone (DDS) in the urine of rabbits. The method is based on the solubility of the hydrochloride of DDS in water and the relative insolubility of the base in water but its ready solubility in ethyl acetate.
Up to 70% of the total diazotizable material excreted in the urine following oral administration of DDS to rabbits has been isolated as unchanged DDS. Not more than about 5% of the diazotizable material may be in an altered form, and this probably as conjugated DDS. Partition chromatography indicated that it was not the acetylated derivative of DDS.
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