Abstract
Summary
1. An in vitro study of the action of Nu 445 shows that this drug occasionally exerts a greater bacteriostatic and bactericidal effect on certain strains of gram negative bacilli than do other sulfonamides.
2. Clinical trial in 20 patients with urinary infections indicated excellent effectiveness of the drug in uncomplicated, monovalent infections due to E. coll or B. proteus.
3. Results of treatment in polyvalent infections and in cases with complicating pathology were poor.
4. The marked lack of toxicity of Nu 445 recommends its use in appropriate cases, in which it will occasionally be found to be more effective than other sulfonamides.
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