Abstract
Summary
1. Hyaluronidase increased the diffusion of fluid across the capillary membrane and cause elevation of the blood hematocrit.
2. Rutin, in the amounts used in these experiments, failed to inhibit this reaction in the albino rat.
3. Rutin in propylene glycol, given intra-peritoneally to the albino rat, caused the formation of hydro-peritoneum and marked hemoconcentration. Propylene glycol given by the same route had a similar, although lesser, effect. When administered orally, rutin caused little elevation of the hematocrit.
The assistance of Miss Elaine Lowry is gratefully acknowledged. The author is indebted to Major Monroe E. Freeman, MSC, for the hyaluronidase preparations.
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