Abstract
Summary
Subcutaneous injection of 2 cc of a “15%” yeast autolysate in rats produced a significant rise in body-temperature. Intraperitoneal injection of the same material produced a significant fall in body-temperature. Both qualitatively and quantitatively similar results were produced by the injection of 2.5 cc of a 0.1% solution of the magnesium salt of yeast nucleic acid. Slight lowering of the body-temperature occurred in some animals after intraperitoneal injection of guanine. Subcutaneous injection of guanine had no effect on body-temperature. Adenine, uracil, xanthine, and allantoin had no effect on the body-temperature of rats by either route of administration.
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