Abstract
Conclusion
Thus far only desoxycorticosterone has been studied with respect to potassium metabolism in the adrenalectomized animal. Under similar conditions it has been previously demonstrated1 that as little as one microgram produces a significant retention of sodium in the adrenalectomized rat. With radiopotassium 10 micrograms can be detected. This method affords a convenient way to evaluate the relative activity of various adrenal cortical steroids and adrenotrophic hormone. Further studies are needed to define the method as a quantitative assay for adrenal cortical steroids.
Summary. By the use of radiopotassium in the adrenalectomized male rat, it is possible to detect as little as 10 μg of desoxycorticosterone. The method affords a convenient means of evaluating the relative activities of adrenal cortical steroids, as well as the influence of adrenotrophic hormone on potassium metabolism.
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