Abstract
Summary
Rats were made diabetic with alloxan and their ability to reproduce was studied under various conditions. The following observations were made: (1) the estrous cycle ceased in diabetic females and was restored by the administration of insulin; (2) 4 of 13 untreated diabetic animals, which were bred before the estrous cycle ceased, produced litters; (3) insulin treated diabetic animals reproduced in spite of a continuing hyperglycemia; (4) transient hyperglycemia did not interfere with reproduction and (5) diabetes in the mother did not result in hyperglycemia in the offspring in the few animals tested.
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