Abstract
Summary
1. Freshly recrystallized pteroyl glutamic acid (PGA)R even in very high concentrations exerts no significant inhibitory effect on the metabolism of brain cell suspensions.
2. PGA preparations, not freshly recrystallized, have a marked inhibitory action in high concentrations (25 millimolar). In lower concentrations (1 millimolar), the inhibition is negligible.
3. The inhibitory action with pyruvate as substrate can be largely accounted for by the photofission product of PGA (2-amino-4-hy-droxy-6-formyl-pteridine).
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