Abstract
Summary
The hyperplasia of the thyroid epithelium produced in rats by exposure to cold-room conditions for 3 weeks can be prevented by increasing the iodide level of the diet. The mechanism of this effect would appear to correspond to the involuting action of iodide in the thyroids of patients with hyperthyroidism. It is difficult to explain these effects on the basis of the inhibition of hormone synthesis, and it is submitted that iodide may stimulate the secretion of colloid into the lumen of thyroid follicles by a mechanism related to its stimulating influence on salivation.
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