Abstract
Summary and Conclusions
The incorporation of 1,000 μg quantities of 5-nitro-2-fural-dehyde-2-β-hydroxyethyl semicarbazone and 5-nitro-2-furaldehyde-2-β-methyl semicarba-zone in paraffin blocks used as salivary stimulants completely prevented acid production in 38 of the 42 saliva samples obtained from caries active individuals. A significant partial reduction in acid formation occurred in the remaining 4 cases. The findings indicate that 5-nitro-2-furaldehyde-2-β-hydroxyethyl semicarbazone and 5-nitro-2-furaldehyde-2-β-methyl semicarbazone are not rapidly destroyed or absorbed by the tissues and fluids of the oral cavity.
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