Abstract
Conclusions
1. Under conditions very favorable for intravenous injection, the “Hypospray” has lodged as much as 97% of the total available drug in the vein, even when administered through the skin and subcutaneous tissues.
2. Large veins are easier to hit than small veins and retain a larger amount of the jet-injected material.
3. The probability of unintentionally penetrating a major vessel with the jet is small but the risk is always present.
4. Jet discharges should not be made in the neighborhood of large vessels unless the drug to be injected is safe for intravenous administration.
5. The jet may produce macroscopically visible damage to a vessel.
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