Abstract
Summary
1. Large doses of aminophyl-line, administered intravenously to dogs, produced a transient elevation in prothrombin activity, followed by a late hypoprothrombinemia with return to normal in about 2 to 3 weeks. Simultaneously, a more marked and persistent rise in Ac-globulin activity occurred. Small doses of 6 mg/kg body wt were without significant effect.
2. No correlation could be found between the Lee-White whole blood clotting time and variations in prothrombin and Ac-globulin activity.
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