Tuberculostatic Effect of Furacin in vitro and in vivo. *

Abstract

Conclusions

1. Furacin exerts a bacteriostatic and bactericidal action on virulent human tubercle bacilli in vitro. In a concentration of 1:20,000 (5 mg %) it prevented growth for 22 days in 4 different types of fluid media. A concentration of 1 : 5000 (20 mg% 0) was required for bactericidal effect.

2. Resistance to Furacin was not evident after many transfers of the H37 Rv culture in drug-containing medium.

3. The combination of Furacin and streptomycin in Tween-albumin liquid medium delayed, but did not prevent, the development of streptomycin-resistance by the H37 Rv tubercle bacillus.

4. Furacin, in the maximum tolerated dose of about 35 mg per kg daily for 64 days, did not appreciably affect the course of tuber-culosis produced in guinea pigs by the human type H37 Rv culture.