Abstract
Summary
A variety of tests were made to determine if superabundant amounts of essential nutrients or optimal amounts of these nutrients from different sources would alter the initiation and development of carious lesions in caries-susceptible cotton rats after tooth development was almost complete. Negative results were obtained in all cases indicating that initiation and development of carious lesions in teeth formed before the beginning of the experimental period were not influenced by additional amounts of the known nutrients tested.
The ration described by Keyes for production of carious lesions in hamsters resulted in very poor growth and a low rate of initiation and development of carious lesions in the cotton rat. A supplement of 8% dried brewer's yeast to the purified ration produced good growth and permitted a slight reduction in the dental caries experience of cotton rats.
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