Abstract
Conclusion
A new quaternary amine, 2,6, dimethyl, diethyl piperidinium bromide, described as a ganglionic blocking agent,4 has an inhibitory or blocking action upon functions mediated by the sympathetic and para-sympathetic divisions of the autonomic nervous system. In dog and in man it reduces blood pressure and prevents several vasomotor reflexes, but does not prevent the vaso-pressor action of epinephrine. It causes a reduction of tone of the stomach and small intestine and abolishes their motor activity, reduces gastric acidity, and causes pupillary dilatation, loss of accommodation, and dryness of mucous membranes. Urecholine causes a reversal of effect on gastric motility. Neostigmine apparently causes a reversal of all effects of the drug.
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