Abstract
Summary
PGA when administered subcutaneously to normal mice in a single injection, produces after 24 hr an effective increase of the total weight and a decrease of the “alkaline” phosphatase of the kidneys. Normal values based on 54 mice are reported and compared with those obtained from 88 mice injected with graded doses of PGA (0.5 mg/kg to 500 mg/kg of body weight). The “alkaline” phosphatase was determined by a slight modification of the colorimetric method of King and Armstrong using disodium phenylphosphate as a substrate. The retention and precipitation of PGA in the renal tubuli, could be responsible for the increased weight and decreased phosphatase activity of the kidneys. Further experiments to determine the mechanism of action of PGA on kidney phosphatase are in progress and will be reported in the near future.
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