Metabolism of Isocysteine,Labeled with Radiosulfur (S 35 ),in the Rat

Abstract

Summary

1. The oxidation of the sulfur of isocysteine by the rat was studied with the aid of isocysteine containing S³⁵.

2. It was found that only a small amount of S³⁵ was excreted as sulfate in the urine within 24 hours after administration of the compound by stomach tube or by intraperitoneal injection. A much larger portion was excreted as organic sulfur. A very small fraction of the S³⁵ was recovered in the feces and intestinal contents of the rats.

3. The results of the present study are compared with those of an earlier investigation in which rabbits served as subjects.